Uphononongo olutshanje ludibanise umthambo womzimba kunye nolunye utshintsho kwisakhiwo se-DNA, ngaphandle kokuguqula ukulandelelana koonobumba bezakhi zofuzo (isakhiwo sokuqala). Izazinzulu kwiSibhedlele i-del Mar Medical Research Institute ziye zaqaphela ukuba ukusebenza ngokuphakathi ngamandla (ukuhamba ngokukhawuleza yonke imihla okanye ukudlala imidlalo ubuncinane imizuzu engama-30) kwandisa izibonelelo.
Ikwazi njani ukutshintsha iDNA?
Indlela yakho yokuphila ichaphazela ngokuthe ngqo i-methylation (inkqubo apho amaqela e-methyl eyongezwa kwi-DNA), kwaye olu tshintsho lunokuthi ludibaniswe nomngcipheko wokwanda kwesifo senhliziyo. Ukuzivocavoca umzimba kunokusebenza kwenye yezinto eziphambili kwi-metabolism ye-triglyceride, leyo, kumazinga aphezulu, yandisa ingozi yesifo senhliziyo. Ngoko ke iinguqu kwi-DNA zinempembelelo kwindlela imizila yemfuza etolikwa ngayo kunye nenqanaba lokuthetha kwazo.
«Indlela yokuphila inempembelelo kwindlela ulwazi oluqulethwe kwiijethi zethu ezichazwe ngayo, kwaye siyazibuza ukuba umsebenzi womzimba uhambelana notshintsho kwenye yezi ndlela zebhayoloji: i-DNA methylation.“, watsho njalo umnxibelelanisi weqela lezazinzulu.
I-Methylation iqulethe utshintsho lweekhemikhali kwi-molecule ye-DNA, ngaphandle kokuguqula ukulandelelana kweeleta, kwaye inqume inqanaba le-gene expression, kunye nokukwazi ukuvelisa okanye kungekhona iiprotheni. Inqanaba le imethylation Kuye kwadityaniswa nezifo ezahlukeneyo ezifana nomhlaza okanye iingxaki zentliziyo, ezifana nesifo seswekile kunye nokukhuluphala.
«Kuhlahlelo siye sabona ukuba abantu abenza umsebenzi omninzi womzimba wokuqina okuphakathi, banamanqanaba asezantsi emethylation kwiindawo ezimbini zeDNA.«, uphawula u-Alba Fernández Sanlés, omnye wababhali bophando.
Kutheni i-methylation ibalulekile?
Njengoko besesitshilo ngaphambili, le nkqubo ilawula ukukwazi kwejini ukuzibonakalisa, kwaye ivelise okanye ingabi neeproteni. «Enye yemfuza esiyifumene ngeenguqu kumanqaku ayo e-methylation inxulumene ne-triglyceride metabolism.", uAlba waphawula. «Sele isaziwa ukuba umsebenzi womzimba unciphisa amanqanaba abo, ngoko ke idatha yethu icebisa ukuba i-methylation yale ndawo ye-DNA ingaba yindlela yokulamla yesiphumo somsebenzi womzimba kubo.«.
Abaphandi bahlalutye amaqela amabini ahlukeneyo: elinye iSpanish kunye nelinye laseMelika. Bebonke abantu abangama-2.544, abaphakathi kweminyaka engama-35 kunye ne-74, bathathe inxaxheba kwaye baphendula imibuzo eqinisekisiweyo luluntu lwezenzululwazi lwamazwe ngamazwe. I-DNA methylation yaphononongwa kwiisampuli zegazi zamavolontiya. Abaphandi bakholelwa ukuba indlela yokuphila ichaphazela ngokuthe ngqo iDNA yethu kwaye olu tshintsho lunokunxulunyaniswa nomngcipheko wokwanda kwesifo sentliziyo.
«Kwizifundo zangaphambili siye sabona ukuba ukusetyenziswa kwecuba kuguqula amanqanaba e-DNA methylation. Ubukho bendlela yokuphila enempilo kubalulekile, okubandakanya umkhuba wokuzivocavoca umzimba ukukhusela izifo zentliziyo.«.