Nangona unxulunyaniswa nofuzo ebomini bakho, indlela ophila ngayo inokuba nempembelelo enkulu kwindlela ezisebenza ngayo ezo mfuza. Apha sizisela umzekelo obalaseleyo: a nuevo studio, epapashwe kwijenali Cell, icebisa ukuba umthambo wokuxhathisa, okufana nokukhwela ibhayisekile kunye nokubaleka, xa kusenziwa ixesha elide, kunokuphucula indlela yofuzo enxulunyaniswa nempilo ye-metabolic.
Ngapha koko, oku akunakunceda kuphela ukukhusela izifo ezinxulumene nomsebenzi wakho we-metabolic, njengeengxaki zentliziyo kunye nohlobo lwe-2 yeswekile, kodwa kwakhona. inokuchaphazela ukusebenza kwezihlunu zakho ekuhambeni kwexesha.
Uphononongo lujonge abantu abangama-40 bebonke, abaphakathi kweminyaka engama-34 nama-53 ubudala, kwaye babahlula bangamaqela amathathu. Iqela lokuqala lenza uqeqesho olunzima lokuchasa ubuncinci iminyaka eyi-15 edlulileyo, iqela lesibini beliqeqeshelwa amandla ubuncinci iminyaka eyi-15 edlulileyo, kwaye iqela lesithathu lalihleli phantsi. I-biopsies ye-skeletal muscle yaqokelelwa kubathathi-nxaxheba kunye nolandelelwano lwe-RNA lwenziwa ukulinganisa umsebenzi ongaphezu kwama-20.000 genes.
Ingaba umthambo wokuxhathisa uzichaphazela njani iijini?
Bafumanise ukuba abantu abakwiqela loqeqesho lokuchasa yatshintsha kakhulu umsebenzi wemfuza engaphezu kwe-1.000 xa kuthelekiswa neqela elihlala phantsi. Uninzi lweejini ezitshintshiweyo zadityaniswa nomsebenzi owandisiweyo kunye neendlela ezininzi zemetabolism, kwaye baqaphela ukuba. kuphela ngama-26 ofuzo atshintshileyo ngoqeqesho lwamandla kuphela, ezinye zazinxulumene nokubaleka nokukhwela ibhayisekile.
Olu phando luye lwanceda ukuqonda ngakumbi malunga nokuba izihlunu 'zitolika' njani iindlela ezahlukeneyo zokuzilolonga kunye nokuziqhelanisa ngeendlela ezithile. Ukongeza, kunokuqondwa ukuba umthambo wokuxhathisa, njengokubaleka kunye nokukhwela ibhayisekile, uchaphazela njani ufuzo olubalulekileyo kwimpilo yemetabolism.
Izivuseleli ezininzi ezahlukeneyo zinokuchaphazela ukubonakaliswa kofuzo lwethu, kubandakanya into esiyityayo nokuba sesichengeni selanga. Olu tshintsho lunceda ukulungelelanisa ngcono imizimba yethu kwizinto ezivuselelayo ezizifumanayo. Yiyo loo nto uqeqesho lokuxhathisa "lufundisa" izihlunu zakho ukuba ziqeqeshe ngokufanelekileyo, kuba iijini ziqhelana nezivuseleli ezizifumanayo, ukuze zenze ngcono kwimisebenzi efanayo elandelayo.
Umzekelo, ezi genes ziya kutshintsha ubungakanani beoksijini ehanjiswa kwizihlunu zakho, ukuze ube nefutha eyaneleyo yokuzivocavoca. Xa amanqanaba e-oksijini ehla ngexesha lokuzilolonga emva kokuzilolonga, ezi genes ziyasebenza ukwenza ukuhanjiswa kweoksijini kusebenze ngakumbi.
Ukuba awukhange uzilolonge iminyaka eli-15 ubuncinci njengabathathi-nxaxheba bophando, akukho mfuneko yokuba ube nexhala. Abaphandi bawela idatha yabo kunye nezifundo zokubonakaliswa kofuzo lwemisipha kubantu abanesifo seswekile se-2 kwaye bafumanisa ukuba inyanga yoqeqesho lokumelana yenze umahluko omkhulu kumsebenzi wemfuza.
Nangona awukwazi ukutshintsha imfuza yakho, unolawulo oluthile kwindlela esebenza ngayo, kwaye akuthathi ixesha elide ukuqala ukubona izibonelelo.