Abasetyhini, ngokukhawuleza okanye kamva, bahlupheke ngenxa yokungabikho kwexesha lokuya esikhathini. Eli nqanaba litsha libizwa ngokuba kukuyeka ukuya exesheni yaye, ukuza kuthi ga namhlanje, akukhange kubonwe ukuba kuya kwenzeka nini na. Kwenzeka nje, kwaye abafazi balinda umzuzu.
Ukuyeka ukuya exesheni kuzisa utshintsho olukhulu lwehomoni, oluchaphazela zombini ubushushu bomzimba, impilo yomzimba nengqondo. Ngoku, uphononongo lwakutsha nje luchonge phantse iinguqu zemfuza ezingama-300 eziphembelela iminyaka yabasetyhini ekuyekeni ukuya exesheni. Iqela lophando kwiDyunivesithi yase-Exeter (e-UK) lifumanise ukuba ezi zantlukwano zemfuzo zinokuqikelela iminyaka eqikelelweyo apho abanye abafazi baya kuyeka ukuya exesheni kwaye bachonge abo basemngciphekweni wokuyeka ukuya exesheni kwangoko.
Iziphumo zinokukhokelela kunyango olungcono lokudlolo kwixesha elizayo kwaye zandise ubude beminyaka yokuzala yabasetyhini. Abaphandi baphinde bavavanya iziphumo ezithile zempilo zokuba nokuyeka ukuya exesheni kwangaphambili okanye kamva. Bafumanisa oko ngokwemfuza Ukuyeka ukuya exesheni kwangaphambili kwandisa umngcipheko wohlobo lwesi-2 seswekile kwaye yayidityaniswe nempilo yamathambo ehlwempuzekileyo kunye nomngcipheko ophezulu wokuphuka. Kodwa bafumanise ukuba ukuyeka ukuya exesheni kwangaphambili kunciphisa umngcipheko wezinye iintlobo zomhlaza, ezinjengomhlaza wesibeleko kunye nomhlaza wamabele.
Ngaphandle kwamathandabuzo, ezi ziphumo ziyakuvula amathuba amatsha okunceda abasetyhini bacwangcisele ikamva. Ngokufumanisa uninzi lwezizathu ezininzi zemfuza zokuguquguquka kwixesha lokuyeka ukuya exesheni, kuye kwaboniswa ukuba ubani unokuqalisa qikelela ukuba ngabaphi abafazi abanokuthi baye exesheni kwangaphambili kwaye ke ngoko kunzima ukukhulelwa ngokwemvelo. Kufuneka kukhunjulwe ukuba bonke abafazi bazalwa ngokuhlukahluka kofuzo, ngoko ke imeko nganye ikhethekileyo kwaye iyingqayizivele.
I-Genetics inokulibazisa ukuyeka ukuya exesheni nge-3 iminyaka
Kuphononongo, abaphandi bahlalutya idatha yofuzo eqokelelwe kubafazi baseYurophu naseMpuma Asia ukusuka kwi-UK Biobank yase-UK, enolwazi lwezempilo kunye nofuzo malunga nesiqingatha sesigidi sabantu. Bakwasebenzise iimpuku zemodeli ukujonga iziphumo zezinye iijini kubomi bokuzala kweempuku.
Kwezi zilwanyana, abaphandi bafumene iintlobo ezimbini zofuzo, Chek1 kunye Chek2, ezichaphazela inzalo kunye nexesha elilindelekileyo lokuphila. Iqela lafumanisa ukuba ukunkqonkqoza i-Chek2 ukuze ingasasebenzi ngelixa i-Chek1 igxininisa kakhulu ukunyusa umsebenzi wokwandisa ubomi bokuzala kwiigundane malunga neepesenti ze-25.
Endaweni yoko, abafazi abo ngokwendalo ukuswela i-Chek2 gene esebenzayo, izazinzulu zafumanisa ukuba ukufikelela exesheni Kwiminyaka eli-3,5 kamva kunamabhinqa anejini eqhelekileyo esebenzayo.
UNjingalwazi uEva Hoffmann, ovela kwiYunivesithi yaseCopenhagen, naye umbhali-mbhali wolu phando, wathi iziphumo zabo "bonelela ngomkhombandlela omtsha onokubakho kwiindlela zonyango ezinokufuna ukunyanga ubudlolo, ngakumbi kunyango lwe ukuchumisa in vitro«.
Wathi: "La ukuchumisa in vitro Isekelwe kwi-hormonal stimulation yabasetyhini. Sifumene ukuba kwenye yeemodeli zethu zempuku, i-Chek2, abasetyhini babenempendulo eyongeziweyo kuvuselelo lwehomoni, okuthetha ukuba amaqanda amaninzi afunyenwe kunyango lokwenyani. in vitro fertilization. LOko kuboniswa ngamaphononongo ethu kukuba kunokwenzeka ukuba ukuvinjelwa kwexesha elifutshane ekujoliswe kuyo kwezi ndlela ngexesha lonyango lwe-IVF kunokunceda abanye abafazi baphendule ngcono.«.