Umdlalo wamanqindi ngumdlalo wonxibelelwano onobungozi, kubo bobabini abachwephesha kunye nabaqalayo. Uphando lwamva nje lwenzululwazi lulumkisa ukuba iimbethi-manqindi ezifumana ukwenzakala okuphindaphindiweyo entloko zinokuba nethuba eliphindwe kathathu lokuphuhlisa i-Alzheimer's.
Abaphandi beYunivesithi yaseBoston bafumanisa ukuba izilonda kumbandela omhlophe wengqondo zinokubonakala kwi-MRI scans. Ngaba izinto ezimhlophe hyperintensitiesa Zibonakala njengamabala aqaqambileyo kwi-brain scans kwaye zingabonisa iimeko ezifana noxinzelelo lwegazi oluphezulu. Nangona kunjalo, izazinzulu ziye zafumanisa ukuba ezi mpawu zixhaphake kakhulu kwiimbaleki eziziqhelanisayo ezemidlalo zoqhagamshelwano ixesha elide okanye abonzakele ngakumbi entloko.
Ukukwazi ukubona ngokulula izikhombisi zomonakalo wobuchopho kwimifanekiso ye-MRI kunokunceda oogqirha. Oku kuya kuthanda uphononongo kunye nokufunyanwa kwangoko kokwenzakala okubangelwa yimpembelelo yentloko.
Iimpembelelo eziphindaphindayo zonyusa ukwenzakala
Iinzuzo ezinokuthi zenziwe ngumdlalo kubantu abatsha zigqwesa lee into yokuba baphumelele phantsi kweemeko ezilawulwa ngokungqongqo. Ngokuqhelekileyo, iimbethi-manqindi zisoloko zixilongwa yaye zihlolwa ingqondo, kodwa ezinye zisenokungaphumeleli.
Kuphononongo, izazinzulu zafunda abantu abaswelekileyo abangama-75 abaye bafumana iimpembelelo zentloko eziphindaphindiweyo ngexesha lobomi babo kwaye bavuma ukunikela ngobuchopho babo kwisayensi yezonyango emva kokufa kwabo, kumndilili weminyaka engama-67.
Iziphumo zibonisa ukuba i-white matter hyperintensities inokubamba ixesha elide umonakalo engqondweni kubantu abanembali ye iimpembelelo eziphinda-phindayo entloko. I-MRI inokuba sisixhobo esisebenzayo sokufunda iziphumo zeempembelelo zentloko eziphindaphindayo kumbandela omhlophe wengqondo ngelixa imbethi manqindi isaphila.
Iimbaleki ubukhulu becala ibingabadlali bebhola ekhatywayo baseMelika, kwaye abanye ibiziimbaleki ezikwimidlalo yonxibelelwano efana namanqindi okanye ibhola ekhatywayo, okanye amagqala omkhosi. Oosonzululwazi baphinde bahlalutya iirekhodi zonyango zomntu ngamnye, kuqukwa nokuhlolwa kwengqondo okwenziwa xa abantu besaphila, kwaye badibana nabantu ababathandayo ukuvavanya iimeko zesifo sengqondo esiyingozi.
Ngokweziphumo ze-autopsy, kwafunyaniswa ukuba iipesenti ezingama-71 zezifundo, abantu abangama-53 bebonke, babenazo. I-encephalopathy engapheliyo yokwenzakala, isifo se-neurodeergenerative esihambelana neempembelelo eziphindaphindiweyo kwintloko enokukhokelela ekudakaleni kwengqondo.
Iimbethi manqindi eziselula zisemngciphekweni omkhulu
Izikena zobuchopho zibonise ukuba kuyo yonke iyunithi umahluko kumthamo we-white matter hyperintensity, amathuba okuba nesifo senqanawa esincinci kunye nomonakalo kumbandela omhlophe wengqondo anyuke kabini.
Oku kukhatshwa kukunyuka okuphindwe kathathu kumathuba okuba a ukuqokelelana kweeprotheyini ezinzima tau kwilobe engaphambili, uphuhliso oluluphawu lwebhayoloji lwezifo ezininzi zobuchopho eziqhubela phambili, kuqukwa nesifo i-Alzheimer's.
Phakathi kweembaleki, ukuba ne-hyperintensities engaphezulu emhlophe kunxulunyaniswa neminyaka emininzi yamanqindi kunye neminye imidlalo yokunxibelelana. Ngokulandelayo, oku kunxulumene namanqaku amabi kakhulu kwiikhweshine malunga nobunzima bokwenza imisebenzi yemihla ngemihla.