Ucwaningo lwakamuva luhlobanise ukuvivinya umzimba noshintsho oluthile ekwakhekeni kwe-DNA, ngaphandle kokuguqula ukulandelana kwezinhlamvu zezakhi zofuzo (isakhiwo esiyinhloko). Ososayensi e-Hospital del Mar Medical Research Institute baye baqaphela ukuthi ukusebenza ngokusesilinganisweni-ngokuqina (ukuhamba ngokushesha nsuku zonke noma ukudlala imidlalo okungenani imizuzu engu-30) kukhulisa izinzuzo.
Ikwazi kanjani ukushintsha i-DNA?
Indlela yakho yokuphila ithonya ngokuqondile i-methylation (inqubo amaqembu e-methyl engezwa ngayo ku-DNA), futhi lezi zinguquko zingase zihlotshaniswe nengozi eyengeziwe yesifo senhliziyo. Ukuvivinya umzimba kungasebenza kwesinye sezici ezibalulekile ku-triglyceride metabolism, okuthi, emazingeni aphezulu, kwandise ingozi yesifo senhliziyo. Ngakho izinguquko ku-DNA zinethonya endleleni izakhi zofuzo ezichazwa ngayo nezinga lokukhuluma kwazo.
«Indlela yokuphila inomthelela endleleni ulwazi oluqukethwe kuzakhi zethu zofuzo oluvezwa ngayo, futhi siyazibuza ukuthi umsebenzi womzimba uhlobene yini noshintsho kwenye yalezi zindlela eziphilayo: i-DNA methylation.“, kuphawula umxhumanisi weqembu lososayensi.
I-Methylation iqukethe ukuguqulwa kwamakhemikhali ku-molecule ye-DNA, ngaphandle kokushintsha ukulandelana kwezinhlamvu, futhi inquma izinga lokuvezwa kofuzo, kanye nekhono lokukhiqiza noma cha amaprotheni. Izinga le i-methylation Kuye kwaxhunyaniswa nezifo ezihlukahlukene ezifana nomdlavuza noma izinkinga zenhliziyo, njengesifo sikashukela nokukhuluphala.
«Ekuhlaziyweni sibonile ukuthi abantu abenza umsebenzi womzimba owengeziwe wokuqina okumaphakathi, banamazinga aphansi e-methylation ezindaweni ezimbili ze-DNA.«, kuphawula u-Alba Fernández Sanlés, omunye wababhali bocwaningo.
Kungani i-methylation ibalulekile?
Njengoba sishilo ngaphambili, le nqubo ilawula amandla ezakhi zofuzo ukuziveza, futhi akhiqize noma angawakhiqizi amaprotheni. «Enye yezakhi zofuzo esizitholile nezinguquko kuzimpawu zayo ze-methylation ihlobene ne-triglyceride metabolism.", kuphawula u-Alba. «Sekuvele kwaziwa ukuthi ukuvivinya umzimba kunciphisa amazinga abo, ngakho-ke idatha yethu iphakamisa ukuthi i-methylation yalesi sizinda se-DNA ingaba indlela yokulamula yomphumela wokusebenza komzimba kubo.".
Abacwaningi bahlaziye amaqembu amabili ahlukene: elilodwa iSpanishi nelinye laseMelika. Isamba sabantu abayizi-2.544, abaphakathi kweminyaka engama-35 nengama-74, ababambe iqhaza futhi baphendula imibuzo eqinisekiswe umphakathi wesayensi womhlaba wonke. I-DNA methylation yacwaningwa kumasampula egazi lamavolontiya. Abacwaningi bakholelwa ukuthi indlela yokuphila iyithinta ngokuqondile i-DNA yethu nokuthi lezi zinguquko zingase zihlotshaniswe nengozi eyengeziwe yesifo senhliziyo nemithambo yegazi.
«Ezifundweni ezedlule siphinde sabona ukuthi ukusetshenziswa kukagwayi kuguqula amazinga e-DNA methylation. Ukuba khona kwendlela yokuphila enempilo kubalulekile, okuhlanganisa umkhuba wokuzivocavoca umzimba ukuvimbela izifo zenhliziyo.".