Mumakore achangopfuura, ruzha rwekutsanya, uye kunyanya kutsanya kwepakati, rakawedzera. Kunyange zvazvo kuderedza uremu kuri iko kudhirowa kukuru kune vakawanda, pane imwe bhenefiti yekutsanya iyo yakamutsa kufarira kukuru. Vatsvagiri vakaona kuti kana muviri wako uchitsanya, unoenda kucheneswa kweserura inonzi autophagy, izvo zvakabatanidzwa nekudzivirira zvirwere uye hupenyu hurefu.
Chii chinonzi autophagy?
Autophagy mukana wekuti maseru ako abvise marara. Iyo inzira yechisikigo yekugadzirisa sero uye kuchenesa. Autophagy inogadzirisa muviri wako uye inoubvumira kuti ushande zvakanyanya.
Funga nezvemasero ako sehovhoni. Nekufamba kwenguva uye sezvaunenge uchikura, masero anounganidza mapuroteni akakuvadzwa, zvidimbu zvakaputsika zvemasero machena eropa, kana ma enzymes uye mamwe ma metabolites asingachashande nemazvo kana nemazvo, senge ovheni yako inounganidza girizi uye grime kubva muchikafu chako. Kana iyi "marara" ikasabviswa, maseru ako haashande kana nemazvo.
Autophagy yakafanana nebasa rekuzvichenesa remasero. Inobvisa marara aya, tsvina inoputika, iyo inofanira kubvisa, asi yakaramba iri pedyo. Masero anobva adzokorodza zvinhu izvi zvehuni uye zvivharo zvekuvaka zvezvikamu zvitsva zvemasero, maererano nechinyorwa chaNdira 2012 muExperimental & Molecular Medicine.
Ndezvipi zvinobatsira zve autophagy?
Zvinoenderana nechinyorwa chiri muExperimental uye Molecular Medicine chataurwa pamusoro apa, autophagy inodiwa kuti masero edu ararame. Inopa zvinovaka muviri uye zvinhu zvekukura kwesero uye kukura, uye inoputsa mapuroteni akakuvadzwa uye zvimwe zvinhu zvinogona kutungamirira kuchirwere uye zvimwe zvakashata zvinokonzerwa nekukwegura.
Nekudaro, kutsvagisa pamusoro pehutano hwakanaka hwe autophagy ichiri mumatanho ekutanga. Zvizhinji zvezvidzidzo zvakaitwa mumasero akadai sembiriso nemhuka, uye hazvina kujeka kana zvakawanikwa zvichidudzira zvakananga kuvanhu.
Pamusoro pezvo, hapana nzira chaiyo yekuyera autophagy muvanhu, sekureva kwaNyamavhuvhu 2017 ongororo yakaburitswa muInternational Journal yeMolecular Sayenzi. Uye, maererano nevanyori veChidzidzo cheJanuary 2015 chakabudiswa muThe Journal of Clinical Investigation (JCI), hazvisi nguva dzose zvakajeka kana migumisiro yacho yakananga kune autophagy kana chimwe chinhu.
Zvakadaro, vaongorori vakaona zvimwe zvinovimbisa zvinogona kubatsira zve autophagy:
kuwedzera hupenyu hurefu
Nekubvisa zvakaunganidzwa uye zvakakuvadzwa cellular zvinhu, autophagy inogona kutungamira mukudzikira kwezvirwere zvine chekuita nezera uye nekuwedzera hupenyu hurefu. Maererano nekudzidza kweJCI, autophagy yakabatsira kuti hupenyu hurefu mumasero, mhuka, uye vanhu.
Kuderera kwengozi yekenza
Ongororo yaMay 2018 yakaburitswa muBiomedicine & Pharmacotherapy yakawana kuti autophagy inogona kudzvinyirira cancer. Muchokwadi, kana majini anodzora autophagy akachinjwa, kune huwandu hwepamusoro hwegomarara.
Imhaka yekuti autophagy inosakura masero anorwara anogona kuita cancer. Nekudaro, vanyori vanocherekedza kuti kune zvakare nguva apo autophagy inodzivirira cancer maseru uye inovabatsira kukura.
Chimwe chinyorwa, chakaburitswa muna Mbudzi 2018 muMakiriniki, chakawana kuti kutsanya-kukonzeresa autophagy kunogona kuita kuti kurapwa kwegomarara kuve kwakanyanya.
Kuwedzera immune system
Pamusoro pekubvisa zvinhu zvisingadiwe zvemaserura, autophagy inogonawo kuuraya mabhakitiriya, mavhairasi, uye mamwe hutachiona hunogona kukonzera hutachiona, sekureva kwaJune 2015 kudzidza kwakabudiswa mu Journal of Experimental Medicine. Zvinobatsirawo kuchengetedza kuzvimba kwemuviri kupindura.
Ngozi yakaderera yechirwere cheurourodegenerative
Vanyori vekutanga 2015 kudzidza vakawanawo kuti autophagy inoita basa mukudzivirira kubva kune neurodegenerative chirwere nekugogodza kunze mapuroteni ane chekuita nemamiriro akaita seAlzheimer's, Huntington's, uye Parkinson's.
Kurongeka kuri nani kweshuga yeropa
Sekureva kwevanyori veBiomedicine uye Pharmacotherapy ongororo, kutsvagisa mumakonzo kunoratidza kuti autophagy inoderedza kufutisa uye insulin kuramba nekubvisa oxidative kusagadzikana uye yakakuvadzwa mitochondria.
Chidzidzo cheKurume 2013 chevakadzi chakabudiswa muBritish Journal of Nutrition chakawana kuti kutsanya kwepakati kwakakonzera kuwedzera insulin senitivity. Yakakwira insulin mazinga anozivikanwa kuve akabatana nemamiriro emetabolism akadai seshuga, chirwere chevascular, uye mazinga epamusoro ekuzvimba.
Sei kutsanya kuchikonzera autophagy?
Autophagy ndiyo imwe nzira iyo muviri unopindura uye unogadzirisa kushushikana. Zvinoenderana neongororo yaNovember 2018 yakaburitswa muAging Research Ongororo, kutsanya ndiyo imwe yedzakanyanya nzira dzekusimudzira autophagy mumuviri.
Munzvimbo ine simba, maseru haafanire kunge achishanda, saka haacheneswe zvakanyanya. Paunenge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchi chema uye haufanirwe kunge uchirasa zvaunazvo .
Asi autophagy inoda kutenderera nekudzima. Kucheneswa kwesero kwakawandisa kana kushoma kunogona kukonzera matambudziko.
Nekudaro, kumunhu wepakati, zvakajairika kuti isu hatipe miviri yedu mukana wekutsanya nekuti tinodya kazhinji, izvo zvinogona kuremedza masisitimu edu. Somugumisiro, unodzivisa mikana yekushandisa mukana uyu unobatsira.
Kunyanya kutsanya kwenguva pfupi, kana uchiganhurira zvaunodya kune dzimwe nguva dzezuva kana mazuva chaiwo evhiki; inzira yekutendera muviri wako kuti uende nepakati penguva dzekudya nekutsanya. Izvi zvinokonzeresa mhinduro yehomoni mumuviri inotyaira kushushikana kwesero, kudzivirira immune system, uye mitochondrial basa (sero simba reimba) mukuwedzera pakuzvichenesa kwayo, sekureva kwaZvita 2019 chinyorwa chakaburitswa muNew England Journal of Medicine. NEJM).
Icho chinonyengera ndechokuti muviri wako unoda kushandura kuchinja kwemetabolism kubva pakupisa glucose (inozivikanwawo seshuga) yehuni kusvika kushandisa mafuta acids uye miviri ye ketone yesimba, maererano nevanyori veNEJM chinyorwa. Izvi zvinogona kutora pakati pe10 ne14 maawa ekutsanya.
Iwe unofanirwa kuedza kutsanya kwepakati kuti upe autophagy?
Kune akawanda mabhenefiti ekutsanya kwepakati kunze kwe autophagy. Uye zviri nyore kutevera. Zvinokurudzirwa kutsanya pakati pe16 ne18 maawa pazuva kuti uwane mabhenefiti. Nekudaro, kutsanya kweanopfuura maawa makumi maviri nemana kunogona kutanga kuwandisa muviri.
Skip breakfast. Iva nekudya kwemasikati uye kudya kwemanheru, uye iwe unogona kuva nehupenyu hwekushamwaridzana. Mukuwedzera, kutsanya kwepakati zvakare Inoshanda zvakanaka nechero pfungwa yekudya, ingave uri paleo, keto, kana gluten-isina kudya.
Asi iwe haufanirwe kuve wakasimba nezve yako yekutsanya chirongwa, kunyanya kana uri kuyedza kutsanya kwepakati nekuda kwezvikonzero zvehupenyu hurefu nekudzivirira chirwere. Iwe urimo kwenguva refu, saka usanetseka nekuti kushushikana kwakaipa pakurarama kwenguva refu. Ingoedza kuenderana. Kunyangwe ukatsanya kaviri pasvondo, zvicharamba zvichibatsira kana uchienzaniswa nekusatsanya zvachose.
Zvisinei, kana uine chirwere cheshuga kana mamwe matambudziko eshuga yeropa, une mimba kana kuyamwisa, vane uremu hushoma, kana kuti vane chirwere chisingaperi chakadai sevascular, itsvo, kana chirwere chechiropa, zvingava zvakanakisisa kudzivisa kutsanya. Nguva dzose bvunza nyanzvi.